To get the best results from Alli it is recommended to be taken in conjunction with exercise and a low calorie, low fat diet. The Alli pill (60mg) should be taken with each meal throughout the day. It is recommended that each meal does not contain more than 15g of fat as this can have undesired effects on bowel movements. Alli can be taken indefinitely and research has shown that unwanted treatment effects lessen with prolonged use.